Clustering regional patterns of left ventricular longitudinal strain in systemic sclerosis-related pulmonary hypertension.

ABSTRACT:

Background

Systemic sclerosis-related pulmonary hypertension (SSc-PH) is a heterogeneous disease, often complicated by concomitant left ventricular (LV) dysfunction. However, the contribution of heterogeneity in LV dysfunction is unclear. The objective in this study was to identify regional clusters of LV longitudinal strain via echocardiography to determine how subgroups of LV dysfunction contribute to mortality in SSc-PH.

Methods

We performed a retrospective observational study on 124 patients with SSc-PH in which LV longitudinal strain was collected over a 16-segment model. We applied K-means clustering to LV longitudinal strain at each segment using the Calinski-Harabasz index. Our primary outcome was time to all-cause mortality.

Results

Patients with SSc-PH were

SUBMITTER: Lui JK 

PROVIDER: S-EPMC11747944 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature