Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review.

ABSTRACT:

Abstract

Recent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whether existing medications for other conditions may affect dementia risk. We conducted a systematic review to identify studies adopting a data-driven approach to investigate the association between a wide range of prescribed medications and dementia risk. We included 14 studies using administrative or medical records data for more than 130 million individuals and 1 million dementia cases. Despite inconsistencies in identifying specific drugs that may modify Alzheimer's or dementia risk, some themes emerged for drug classes with biological plausibility. Antimicrobials, vaccinations, and ant

SUBMITTER: Underwood BR 

PROVIDER: S-EPMC11747987 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature