Reward Decision Network Disconnection in Poststroke Apathy: A Prospective Multimodality Imaging Study.

ABSTRACT: Apathy is a common neuropsychiatric symptom following stroke, characterized by reduced goal-directed behavior. The reward decision network (RDN), which plays a crucial role in regulating goal-directed behaviors, is closely associated with apathy. However, the relationship between poststroke apathy (PSA) and RDN dysfunction remains unclear due to apathy heterogeneity, the confounding effect of depression and individual variability in lesion impacts. This study aims to dissect the heterogeneity of PSA and explore the link between lesion-induced RDN damage and PSA. We prospectively recruited 207 patients with acute ischemic infarction and 60 demographically matched healthy controls. Participants underwent neuroimaging and longitudinal neuropsychiatric assessments. To characterize PSA heteroge

SUBMITTER: Fang Y 

PROVIDER: S-EPMC11747988 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature