Eye reactions under the influence of drugs of abuse as measured by smartphones: a controlled clinical study in healthy volunteers.

ABSTRACT:

Background

It is known that illicit and prescribed drugs impact pupil size, eye movement and function. Still, comprehensive quantitative evaluations under known ambient light conditions are lacking, when smartphones are used for monitoring.

Methods

In this clinical study (NCT05731999), four medicinal products with addiction risks were administered to 48 subjects (18-70 years old, all with informed consent, 12 subjects per drug). Videos captured by smartphones at ~50 lux and ~ 500 lux documented the eye's reaction before and after controlled intake of single doses of oral oxycodone (20 mg), lorazepam (2 mg), lisdexamphetamine (70 mg) and inhaled cannabis flos (65 mg with 22% THC) over a 5-h test period. Data from three observational tests, non-convergence (NC, ability to cros

SUBMITTER: Kuijpers KWK 

PROVIDER: S-EPMC11748063 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature