Association between osteoarthritis and cognitive function: results from the NHANES 2011-2014 and Mendelian randomization study.

ABSTRACT:

Background

Previous meta-analyses have demonstrated osteoarthritis (OA) is associated with an increased risk of dementia, but these studies were prone to bias based on residual confounding factors and reverse causality.

Objectives

We aimed to investigate associations between OA and cognitive function using data from the National Health and Nutrition Examination Survey (NHANES) and to investigate the causality using Mendelian randomization (MR).

Design

This is a cross-sectional study and MR study.

Methods

Data from the NHANES 2011-2014 were used. Multiple linear, logistic regressions and stratified analyses were used to determine the association between OA status and cognitive function. Sample weights were used to ensure result generalizability. Two-sample MR an

SUBMITTER: Zhao K 

PROVIDER: S-EPMC11748087 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature