Extracellular vesicles in ZIKV infection: Carriers and facilitators of viral pathogenesis?

ABSTRACT: Zika virus (ZIKV) is a flavivirus of significant epidemiological importance, utilizing various transmission strategies and infecting "immune privileged tissues" during both the pre- and postnatal periods. One such transmission method may involve extracellular vesicles (EVs). EVs can travel long distances without degrading, carrying complex messages that trigger different responses in recipient cells. They can easily cross specialized tissue barriers, such as the placental barrier and the blood-brain barrier, which protects the central nervous system. It is known that some viruses can hijack and exploit the EVs biogenesis machinery to package regulatory elements, viral segments, and even complete viral genomes. This allows them to evade the immune system, amplify their tropism, and enhance

SUBMITTER: Calderon-Pelaez MA 

PROVIDER: S-EPMC11748155 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature