Annexin A8 deficiency delays atherosclerosis progression.

ABSTRACT:

Background

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids and leukocytes within the arterial wall. By studying the aortic transcriptome of atherosclerosis-prone apolipoprotein E (ApoE^-/-) mice, we aimed to identify novel players in the progression of atherosclerosis.

Methods

RNA-Seq analysis was performed on aortas from ApoE^-/- and wild-type mice. AnxA8 expression was assessed in human and mice atherosclerotic tissue and healthy aorta. ApoE^-/- mice lacking systemic AnxA8 (ApoE^-/-AnxA8^-/-) were generated to assess the effect of AnxA8 deficiency on atherosclerosis. Bone marrow transplantation (BMT) was also performed to generate ApoE^-/- lacking AnxA8 specifically in

SUBMITTER: Gutierrez-Munoz C 

PROVIDER: S-EPMC11748212 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature