Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia.

ABSTRACT:

Background

Early-onset schizophrenia (EOS) occurs between the ages of 13 and 17 years, and neurobiological factors leading to cognitive deficits and psychotic symptoms with varying degrees of positive and negative symptoms. Numerous studies have demonstrated a broad link between immune dysregulation and the central nervous system in EOS, and its pathogenesis involves immune dysfunction, but the exact biological mechanisms have not been elucidated. This study employs immune infiltration analysis and bioinformatics to unveil the pathogenic mechanisms of EOS and identify potential diagnostic biomarkers, aiming for more precise clinical interventions.

Methods

In this study, we recruited 26 EOS patients and 27 healthy controls (HCs), and microarray data were collected. Crossover

SUBMITTER: Wu S 

PROVIDER: S-EPMC11748289 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature