Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.

ABSTRACT:

Background

Antibiotics, as the most commonly prescribed class of drugs in neonatal intensive care units, have an important impact on the developing neonatal gut microbiota. Therefore, comprehending the effects of commonly used antibiotic therapy on the gut microbiota and butyrate-producers in early infants could provide information for therapeutic decision-making in the NICU.

Objectives

To explore the effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.

Methods

A total of 72 infants were included in the study. We performed 16S rRNA sequencing on stool swab samples collected from neonatal intensive care unit patients who received amoxicillin-clavulanic acid (AC, n = 10), moxalactam (ML, n = 28)

SUBMITTER: Qiu J 

PROVIDER: S-EPMC11748296 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature