TREM2 promotes the formation of a tumor-supportive microenvironment in hepatocellular carcinoma.

ABSTRACT:

Background

Triggering receptor expressed on myeloid cells 2 (TREM2), a surface receptor predominantly expressed on myeloid cells, is a major hub gene in pathology-induced immune signaling. However, its function in hepatocellular carcinoma (HCC) remains controversial. This study aimed to evaluate the role of TREM2 in the tumor microenvironment in the context of HCC progression.

Methods

HCC was experimentally induced in wild-type (WT) and Trem2-deficient (Trem2^-/-) mice, and clinical sample analysis and in vitro studies on macrophages were conducted. HCC cells were treated with conditioned medium from WT or Trem2^-/- macrophages, and their malignant phenotypes and underlying mechanisms were analyzed.

Results

TREM2 deficiency reduced liver tumor burd

SUBMITTER: Guo H 

PROVIDER: S-EPMC11748316 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature