D-mannose promotes diabetic wound healing through inhibiting advanced glycation end products formation in keratinocytes.

ABSTRACT:

Background

Diabetic chronic foot ulcers pose a significant therapeutic challenge around the world, resulting in adverse effects and complications in patients. D-mannose is enriched in cirtus peel and exerts beneficial effects among various diseases, especially against inflammation-related disorders.

Methods

Here, we examined the potential effect of D-mannose during wound healing process in streptozotocin (STZ)-induced diabetes mice in vivo and by culturing keratinocytes under high glucose condition in vitro. The skin lesion healing was recorded in photos and evaluated by histochemical staining. What's more, the advanced glycation end products (AGEs) concentration in blood and mice skin was quantified. Apoptotic cells were assessed by flow cytometry and Western blotting. Infl

SUBMITTER: Luo J 

PROVIDER: S-EPMC11748336 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature