NKX6.3 modulation of mitotic dynamics and genomic stability in gastric carcinogenesis.

ABSTRACT:

Background

Gastric cancer remains a significant global health challenge, characterized by poor prognosis and high mortality rates. Mitotic integrity and genomic stability are crucial in maintaining cellular homeostasis and preventing tumorigenesis. The transcription factor NKX6.3 has emerged as a potential regulator of these processes in gastric epithelial cells, prompting an investigation into its role in gastric cancer development.

Methods

We employed a combination of in vitro and in vivo techniques to elucidate the impact of NKX6.3 depletion on mitotic dynamics and genomic stability in gastric epithelial cells. Quantitative real-time PCR and Western blot analyses were conducted to assess the expression of mitosis-related genes and proteins. Flow cytometry was utilized to

SUBMITTER: Yoon JH 

PROVIDER: S-EPMC11748348 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature