Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review.

ABSTRACT: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition characterized by liver steatosis, inflammation, consequent fibrosis, and cirrhosis. Chronic impairment of lipid metabolism is closely related to oxidative stress, leading to cellular lipotoxicity, mitochondrial dysfunction, and endoplasmic reticulum stress. The detrimental effect of oxidative stress is usually accompanied by changes in antioxidant defense mechanisms, with the alterations in antioxidant enzymes expression/activities during MASLD development and progression reported in many clinical and experimental studies. This review will provide a comprehensive overview of the present research on MASLD-induced changes in the catalytic activity and expression of the main antioxidant enzymes (supe

SUBMITTER: Svobodova G 

PROVIDER: S-EPMC11748479 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature