Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response.

ABSTRACT: Porcine reproductive and respiratory syndrome virus (PRRSV) presents significant economic challenges to the global pork industry due to its ability to mutate rapidly. The current commercial vaccines have limited effectiveness, and there are strict restrictions on the use of antiviral chemical drugs. Therefore, it is urgent to identify new strategies for preventing and controlling PRRSV infections. Baicalein, a flavonoid derived from Scutellaria baicalensis, has gained attention for its potential antiviral properties. However, there is little information about the effects and mechanisms of baicalein in relation to PRRSV. In this study, a network pharmacology analysis identified seven potential targets of baicalein against PRRSV, with the epidermal growth factor receptor (EGFR) emerging as t

SUBMITTER: Wu J 

PROVIDER: S-EPMC11748510 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature