Designing host-associated microbiomes using the consumer/resource model.

ABSTRACT: A key step toward rational microbiome engineering is in silico sampling of realistic microbial communities that correspond to desired host phenotypes, and vice versa. This remains challenging due to a lack of generative models that simultaneously capture compositions of host-associated microbiomes and host phenotypes. To that end, we present a generative model based on the mechanistic consumer/resource (C/R) framework. In the model, variation in microbial ecosystem composition arises due to differences in the availability of effective resources (inferred latent variables), while species' resource preferences remain conserved. Simultaneously, the latent variables are used to model phenotypic states of hosts. In silico microbiomes generated by our model accurately reproduce uni

SUBMITTER: Plata G 

PROVIDER: S-EPMC11748559 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature