CRYβB2 alters cell adhesion to promote invasion in a triple-negative breast cancer cell line.

ABSTRACT:

Objective

African American women with breast cancer experience disproportionately poor survival outcomes, primarily due to the high prevalence of the deadliest subtype; triple-negative breast cancer (TNBC). The CRYβB2 gene is upregulated in tumors from African American patients across all breast cancer subtypes, including TNBC, and is associated with worse survival rates. This study investigated the effect of CRYβB2 on the invasion of TNBC cells and the underlying mechanisms contributing to this phenotype.

Results

We utilized the SUM159 cells with stable CRYβB2 overexpression in a 3D-culture tumor spheroids model in our investigation. A quantitative 3D invasion assay demonstrated that CRYβB2 overexpression significantly enhanced invasion (median invasion %; SUM159 = 0.14 and

SUBMITTER: Waly AA 

PROVIDER: S-EPMC11748568 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature