Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study.

ABSTRACT:

Background

Type 2 diabetes (T2D) has been linked to changes in DNA methylation levels, which can, in turn, alter transcriptional activity. However, most studies for epigenome-wide associations between T2D and DNA methylation comes from cross-sectional design. Few large-scale investigations have explored these associations longitudinally over multiple time-points.

Methods

In this longitudinal study, we examined data from the Cooperative Health Research in the Region of Augsburg (KORA) F4 and FF4 studies, conducted approximately seven years apart. Leucocyte DNA methylation was assessed using the Illumina EPIC and 450K arrays. Linear mixed-effects models were employed to identify significant associations between methylation sites and diabetes status, as well as with fasting pla

SUBMITTER: Lai L 

PROVIDER: S-EPMC11748594 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature