M cells targeted H. pylori antigen SAM-FAdE displayed on bacterium-like particles induce protective immunity.

ABSTRACT:

Background

Helicobacter pylori (H. pylori), a specific bacterium capable of surviving in the acidic environment of the stomach, has been recognized as a group of causative agents of gastric cancer. Therefore, the development of mucosal vaccines against H. pylori is expected to provide an important direction for the treatment of chronic gastritis and the prevention of gastric cancer.

Methods and results

In this study, we used bacteria-like particles (BLPs) obtained by treating Lactic acid bacteria (L. lactis) with hot acid, and successfully displayed the M cell-targeted H. pylori multi-epitope purified antigen SAM-FAdE, with 90% display efficiency. In addition, BLPs-SAM-FAdE can effectively target M ​​cell models and M cells of mouse Peyer's patches (PPs) through oral immuniz

SUBMITTER: Zhang F 

PROVIDER: S-EPMC11748607 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature