Compact and cGMP-compliant automated synthesis of [¹⁸F]FSPG on the Trasis AllinOne™.

ABSTRACT:

Background

(S)-4-(3-¹⁸F-Fluoropropyl)-ʟ-glutamic acid ([¹⁸F]FSPG) is a positron emission tomography radiotracer used to image system x_c^-, an antiporter that is upregulated in several cancers. Not only does imaging system x_c^- with [¹⁸F]FSPG identify tumours, but it can also provide an early readout of response and resistance to therapy. Unfortunately, the clinical production of [¹⁸F]FSPG has been hampered by a lack of robust, cGMP-compliant methods. Here, we report the automated synthesis of [¹⁸F]FSPG on the Trasis AllinOne™, overcoming previous limitations to provide a user-friendly method ready for clinical adoption.

Results

The optimised method provided [¹⁸F]FSPG i

SUBMITTER: Farooq R 

PROVIDER: S-EPMC11748660 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature