Genome-wide localization of mobile elements: experimental, statistical and biological considerations.

ABSTRACT:

Background

The distribution and location of insertion elements in a genome is an excellent tool to track the evolution of bacterial strains and a useful molecular marker to distinguish between closely related bacterial isolates. The information about the genomic locations of IS elements is available in public sequence databases. However, the locations of mobile elements may vary from strain to strain and within the population of an individual strain. Tools that allow de novo localization of IS elements and are independent of existing sequence information are essential to map insertion elements and advance our knowledge of the role that such elements play in gene regulation and genome plasticity in bacteria.

Results

In this study, we present an efficient and reliable method f

SUBMITTER: Martinez-Vaz BM 

PROVIDER: S-EPMC1174868 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature