Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats.

ABSTRACT: The anterior cingulate cortex is responsible for multiple cognitive functions like fear, pain management, decision-making, risk and reward assessment, and memory consolidation. However, its cell-type-specific functions are not clearly understood. To reveal the selective functional role of Parvalbumin-expressing GABAergic interneurons in the ACC, we knocked down (KD) the PV gene in-vivo in rats. Behavioral tests showed significantly improved spatial memory (p = 0.01) in ACC-PV-KD rats compared to control and sham groups, whereas novel object recognition memory was reduced significantly (p = 0.001). The PV knockdown group also showed a longer freezing duration (p = 0.001) and considerably fewer freezing responses (p = 0.005) in the fear conditioning chamber. Addit

SUBMITTER: Jahangir M 

PROVIDER: S-EPMC11748682 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature