⁶⁸Ga-NOTA-RM26 PET/CT in the evaluation of glioma: a pilot prospective study.

ABSTRACT:

Background

Gliomas are the most common malignant primary tumors of the central nervous system. There is an urgent need for new convenient, targeted and specific imaging agents for gliomas. This study aimed to firstly evaluate the feasibility of ⁶⁸Ga-NOTA-RM26 PET/CT imaging in glioma and analyze the relationship between the imaging characteristics and glioma grade, classification and molecular alterations.

Results

Twenty-two patients were confirmed as glioma by surgery or biopsy. All patients exhibited ⁶⁸Ga-NOTA-RM26 uptake. SUV_max was chosen as the imaging marker for analysis. For all glioma patients, there were significant differences between grades (P = 0.047). For primary gliomas, SUV_max had good discrimination for both tumor c

SUBMITTER: Li Y 

PROVIDER: S-EPMC11748694 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature