Low apolipoprotein A1 and high apolipoprotein B levels indicate specific lipid changes in treatment naive early psoriatic arthritis.

ABSTRACT:

Objectives

To investigate serum lipid profile in early, treatment-naïve psoriatic arthritis (PsA) and to determine whether changes in classical lipids or apolipoproteins are specific to PsA.

Methods

Total cholesterol, non-high-density lipoprotein cholesterol (non-HDL-c), low-density lipoprotein cholesterol (LDL-c), HDL-c, triglycerides, apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1) were compared in newly diagnosed untreated PsA patients (n=75) to sex- and age-matched controls (healthy control (HC)) (n=61) and early untreated rheumatoid arthritis (RA) patients (n=50).

Results

Among classical lipid measurements, HDL-c levels were lower in PsA than in HC and RA (df 2, χ²10, p=0.006, PsA vs HC p=0.013). Significant differences in ApoA1 and ApoB levels w

SUBMITTER: Ishchenko A 

PROVIDER: S-EPMC11748773 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature