Differential pathological changes in colon microenvironments in acute and chronic mouse models of inflammatory bowel disease.

ABSTRACT: Inflammatory bowel disease is a chronic condition characterized by inflammation of the gastrointestinal tract, resulting from an abnormal immune response to normal stimuli, such as food and intestinal flora. Since the etiology of this disease remains largely unknown, murine models induced by the consumption of dextran-sodium sulfate serve as a pivotal tool for studying colon inflammation. In this study, we employed both acute and chronic colitis mouse models induced by varying durations of dextran-sodium sulfate consumption to investigate the pathological and immunologic characteristics throughout the disease course. During the acute phase, activated innate inflammation marked by M1 macrophage infiltration was prominent. In contrast, the chronic phase was characterized by tissue remodeling

SUBMITTER: Ham N 

PROVIDER: S-EPMC11748878 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature