Effects of intranasal oxytocin on neural reward processing in children and adolescents with reactive attachment disorder: A randomized controlled trial.

ABSTRACT: Reactive attachment disorder (RAD) is associated with socially and emotionally withdrawn/inhibited behaviors and reduced neural responses to rewards. Children and adolescents with RAD show aberrant attachment behaviors, and existing psychotherapies are difficult to maintain; therefore, pharmacological interventions to aid and boost treatment responses are needed. Oxytocin (OT) administration is known to promote reward functioning. We investigated whether single-use intranasal OT administration improved neural responses during reward processing in patients with RAD compared with healthy controls. Twenty-four male children and adolescents with RAD (10-18 years old) and 27 age- and sex-matched typically developing individuals (10-17 years old) were included in this randomized, double-blind, p

SUBMITTER: Takiguchi S 

PROVIDER: S-EPMC11748893 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature