Prognostic factors for transplant-free survival in patients with secondary sclerosing cholangitis associated with critical illness.

ABSTRACT:

Objective

Secondary sclerosing cholangitis (SSC) represents a disease with a poor prognosis increasingly diagnosed in clinical settings. Notably, SSC in critically ill patients (SSC-CIP) is the most frequent cause. Variables associated with worse prognosis remain unclear. The primary aim of this study was to identify factors associated with transplant-free survival in SSC-CIP patients using readily available data.

Methods

A cohort of 47 patients diagnosed with SSC-CIP was retrospectively analysed for clinical, biochemical and endoscopic variables. Kaplan-Meier survival curves, log-rank tests and univariate Cox proportional hazards models were used to assess associations with transplant-free survival. A multivariable Cox regression model was constructed using Lasso regularisa

SUBMITTER: Konstantis G 

PROVIDER: S-EPMC11748924 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature