Differential impact of TIM-3 ligands on NK cell function.

ABSTRACT:

Background

The transmembrane protein T-cell immunoglobulin and mucin-domain containing molecule 3 (TIM-3) is an immune checkpoint receptor that is expressed by a variety of leukocyte subsets, particularly in the tumor microenvironment. An effective TIM-3-targeting therapy should account for multiple biological factors, including the disease setting, the specific cell types involved and their varying sensitivities to the four putative TIM-3 ligands (galectin-9, phosphatidylserine, high mobility group protein B1 and carcinoembryonic antigen cell adhesion molecule 1), each of which engages a unique binding site on the receptor's variable immunoglobulin domain. The primary objectives of this study were to assess the prevalence and function of TIM-3⁺ natural killer (NK) cells

SUBMITTER: Wang J 

PROVIDER: S-EPMC11748930 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature