Impaired coagulation parameters in early RA are restored by effective antirheumatic therapy: a prospective pilot study.

ABSTRACT:

Objectives

To assess the effect of treatment on haemostatic parameters in patients with early rheumatoid arthritis (RA).

Methods

Patients with newly diagnosed RA started methotrexate and were randomised to additional conventional treatment, certolizumab pegol, abatacept or tocilizumab. Several biomarkers for haemostasis were analysed including parameters of the two global haemostatic assays-overall haemostatic potential (OHP) and endogenous thrombin potential (ETP), as well as single haemostatic factors-fibrinogen, prothrombin fragment 1+2 (F1+2), D-dimer, thrombin activatable fibrinolysis inhibitor (TAFI) and clot lysis time (CLT) in 24 patients at baseline, 12 and 24 weeks after the start of the treatment.

Results

At baseline, patients had elevated levels of the fol

SUBMITTER: Dijkshoorn B 

PROVIDER: S-EPMC11748942 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature