Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern.

ABSTRACT: The monocarboxylate transporter 1 (MCT1), encoded by gene Slc16a1, is a proton-coupled transporter for lactate and other monocarboxylates. MCT1-mediated lactate transport was recently found to regulate various biological functions. However, how MCT1 and lactate in the intestine modulate the physiology and pathophysiology of the body is unclear. In this study, we generated a mouse model with specific deletion of Slc16a1 in the intestinal epithelium (Slc16a1 ^IKO mice) and investigated the functions of MCT1 in the gut. When fed a high-fat diet, Slc16a1 ^IKO male mice had improvement in glucose tolerance and insulin sensitivity, while Slc16a1 ^IKO female mice only had increased adiposity. Deficiency of intestinal MCT1 in male mi

SUBMITTER: Wang S 

PROVIDER: S-EPMC11748985 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature