Dysfunctional large-scale brain networks in drug-naive depersonalization-derealization disorder patients.

ABSTRACT:

Background

Depersonalization-Derealization Disorder (DPRD) presents challenges in understanding its neurobiological underpinnings. Several neuroimaging studies have revealed altered brain function and structure in DPRD. However, the knowledge about large-scale dysfunctional brain networks in DPRD remains unknown.

Methods

A total of 47 drug-naïve DPRD patients and 49 healthy controls (HCs) were recruited and underwent resting-state functional scanning. After constructing large-scale brain networks, we calculated within-and between-network functional connectivity (FC) using the Schaefer and Tian atlas. The Support Vector Machine (SVM) model was employed to classify DPRD patients and provide features for DPRD patients concerning the dysfunctional large-scale brain networks. Fin

SUBMITTER: Zheng S 

PROVIDER: S-EPMC11749103 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature