Nicotinamide riboside supplementation ameliorates ovarian dysfunction in a PCOS mouse model.

ABSTRACT: Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility among women of reproductive age, yet the range of effective treatment options remains limited. Our previous study revealed that reduced levels of nicotinamide adenine dinucleotide (NAD⁺) in ovarian granulosa cells (GCs) of women with PCOS resulted in the accumulation of reactive oxygen species (ROS) and mitochondrial dysfunction. However, it is still uncertain whether increasing NAD⁺ levels in the ovaries could improve ovarian function in PCOS. In this study, we demonstrated that supplementation with the NAD⁺ precursor nicotinamide riboside (NR) prevented the decrease in ovarian NAD⁺ levels, normalized estrous cycle irregularities, and enhanced ovulation potential in

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC11749135 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature