Risk-based triage strategy by extended HPV genotyping for women with ASC-US cytology.

ABSTRACT:

Objective

We attempted to evaluate the immediate high-grade squamous intraepithelial lesion-cervical intraepithelial neoplasia grade 2/3 or worse (HSIL-CIN2+/3+, hereafter referred to as CIN2+/3+) risk of specific human papillomavirus (HPV) genotype and form the precise risk-based triage strategy for atypical squamous cells of undetermined significance (ASC-US) women.

Methods

The clinical data of ASC-US women who underwent HPV genotyping testing and colposcopy were retrospectively reviewed. The distribution and CIN2+/3+ risks of specific HPV genotype were assessed by three approaches. The risk-based triage strategy was further established, and its efficacy in detecting CIN2+/3+ was estimated.

Results

Totally, 5553 ASC-US women including 3648 HPV-positive and 1905 HPV-

SUBMITTER: Rao X 

PROVIDER: S-EPMC11749152 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature