Dietary choline and sphingomyelin choline moiety intake and risk of colorectal cancer: a case-control study.

ABSTRACT:

Introduction

Phospholipids are possible favorable agents for colorectal cancer (CRC). Choline has been inversely related to CRC risk but findings are inconsistent. We assessed the effect of dietary sphingomyelin (SM) choline moiety and total choline intake on risk of CRC.

Method

This analysis is based on a multicenter case-control study conducted between 1992 and 1996 in Italy. A total of 6107 subjects were enrolled, including 1225 colon cancer cases, 728 rectal cancer cases and 4154 hospital-based controls. We applied data on the composition of foods in terms of SM choline moiety and choline intake on dietary information collected through a validated food-frequency questionnaire. Odds ratio (OR) for energy-adjusted tertiles of SM choline moiety and choline were estimated th

SUBMITTER: Rossi M 

PROVIDER: S-EPMC11749154 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature