Purinergic signaling by TCRαβ⁺ double-negative T regulatory cells ameliorates liver ischemia-reperfusion injury.

ABSTRACT: Hepatic ischemia-reperfusion injury (HIRI) is an important cause of liver injury following liver transplantation and major resections, and neutrophils are the key effector cells in HIRI. Double-negative T regulatory cells (DNT) are increasingly recognized as having critical regulatory functions in the immune system. Whether DNT expresses distinct immunoregulatory mechanisms to modulate neutrophils, as in HIRI, remains largely unknown. In this study, we found that murine and human DNT highly expressed CD39 that protected DNT from extracellular ATP-induced apoptosis and generated adenosine in tandem with CD73, to induce high levels of neutrophil apoptosis. Furthermore, extracellular adenosine enhanced DNT survival and suppressive function by upregulating survivin and NKG2D expression via the

SUBMITTER: Jin H 

PROVIDER: S-EPMC11749161 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature