Reducing opioid consumption levels post-operatively following gastrointestinal surgery - A systematic review of randomized trials.

ABSTRACT:

Background

The opioid crisis has reached epidemic proportions worldwide. Unfortunately, prescription of opioid analgesia in the post-operative phase of treatment is contributing to this problem. We aimed to perform a systematic review of randomized controlled trials to establish methods of reducing opioid toxicity following gastrointestinal surgery.

Materials and methods

A systematic review was performed in accordance to the PRISMA guidelines. Randomized controlled trials were included. The risk of bias 2.0 assessment was used to determine potential bias.

Results

In total, 14 prospective, randomized trials involving 1,687 patients (mean age: 50 years (range: 21-80) were included in this systematic review. Overall, 42.9% of trials reported outcomes in relation to intra

SUBMITTER: Davey MG 

PROVIDER: S-EPMC11749179 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature