Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in <i>Apoe^-/-</i> mice.

ABSTRACT: Atherosclerosis is the major contributor to cardiovascular mortality worldwide. Alternate day fasting (ADF) has gained growing attention due to its metabolic benefits. However, the effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in atherosclerotic animal models. The present study was designed to investigate the effects of ADF on atherosclerosis in apolipoprotein E-deficient (Apoe ^-/- ) mice. Eleven-week-old male Apoe ^-/- mice fed with Western diet (WD) were randomly grouped into ad libitum (AL) group and ADF group, and ADF aggravated both the early and advanced atherosclerotic lesion formation, which might be due to the disturbed cholesterol profiles caused by ADF intervention. ADF significant

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11749235 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature