Biochemical evaluation of novel thiazolone derivatives as dual α-glucosidase/α-amylase inhibitors, anti-inflammatory agents.

ABSTRACT:

Background

Using an analogue-based drug design approach, a number of novel 2-substituted-1,3-thiazolone derivatives (3-10) have been produced and given permission to proceed for their anti-inflammatory properties. In the present paper, the new thiazole derivatives were designed, synthesized, and tested for their alpha-glucosidase, alpha-amylase, and COX-inhibitory activities. Approving the anti-diabetic activity.

Results

All the new derivatives were assessed in vitro compared to control (Acarbose) alpha-glucosidase, and alpha-amylase inhibition influence was showed shown through (3, 5, and 7) that were the most effective compounds as α-glucosidase inhibitors.

Conclusions

Compounds (4 and 7) achieved the best effect as α-amylase inhibitors showed by IC₅₀ sco

SUBMITTER: Abdelhamid MS 

PROVIDER: S-EPMC11749350 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature