Sensory alterations and immunological changes during the chronification of postsurgical pain: a study protocol for a prospective observational cohort study.

ABSTRACT:

Introduction

Chronic postsurgical pain (CPSP) represents a widely underdiagnosed and often poorly treated medical problem, affecting 10-50% of all surgical patients, exhibiting neuropathic features in 35-60%. It is hypothesised that surgery-induced tissue damage and the subsequent immune response cause sensory alterations in the early postoperative period, ultimately leading to a chronic neuropathic or nociplastic pain state. The 'Sensory Changes and Immunological parameters in Postsurgical pain' study (SCIP-Pain study) was designed to test this hypothesis and identify sensory alterations and changes in the immunological response that are related to the development of CPSP with neuropathic features.

Methods and analysis

This protocol describes the SCIP-Pain study-an ongoing

SUBMITTER: van Driel MEC 

PROVIDER: S-EPMC11749363 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature