Synthesis, characterization, and enzyme inhibition evaluation of sitagliptin derivatives and their metal complexes.

ABSTRACT:

Aims

This study focuses on the synthesis and characterization of novel sitagliptin derivatives, aiming to develop potent, orally active anti-diabetic agents with minimal side effects for the management of type 2 diabetes mellitus. Copper (II) (SCu1-SCu9) and zinc (II) (SZn1-SZn9) metal complexes of sitagliptin-based derivatives were synthesized via a template reaction.

Material & method

The synthesized complexes were comprehensively characterized using elemental analysis, FTIR, UV-Vis, 1 h NMR, and 13C NMR spectroscopy. The biological efficacy of these compounds was assessed through α-amylase and α-glucosidase enzyme inhibition assays, with molecular simulation studies providing additional confirmation of their inhibitory activity.

Results

Among the tested derivatives

SUBMITTER: Ahmed J 

PROVIDER: S-EPMC11749388 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature