Clinicopathological and prognostic significance of exosomal PD-L1 in cancer therapy.

ABSTRACT:

Aim

The exosomal programmed death ligand-1(exoPD-L1) has recently become a topic of interest in the field of oncology. But the prognostic role of exoPD-L1 in cancer patients is inconsistent across previous studies. Therefore, a quantitative meta-analysis was performed to evaluate the prognostic and clinicopathological value of exoPD-L1 in cancer patients.

Materials and methods

Twenty eligible studies were included in this study. The relationship between baseline level of exoPD-L1 and clinicopathological features, therapeutic response, overall survival (OS) and progression-free survival (PFS) was evaluated.

Results

Pooled analysis indicated that high level of exoPD-L1 was significantly associated with higher tumor stage, positive lymph node metastasis, and advanced TNM

SUBMITTER: Hu S 

PROVIDER: S-EPMC11749390 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature