Excessive activation of JAK-STAT signaling contributes to inflammation induced by acute <i>Vibrio</i> infection in shrimp.

ABSTRACT: Uncontrolled immune responses resulting from overactivated cellular signaling pathways, leading to inflammation and tissue injury, are a major cause of death in pathogen-infected individuals. This phenomenon has been well studied in mammals but is less explored in invertebrates. Bacteria of the genus Vibrio are among the most harmful pathogens to humans and aquatic animals. In shrimp, Vibrio infection is generally characterized by the sudden onset of disease, with pathological signs of opaque and whitish muscle tissue. The current study shows that shrimp acutely infected with high dose of Vibrio parahaemolyticus develop inflammation-like pathological changes, leading to rapid death. Excessive activation of JAK-STAT signaling, rather than the Dorsal and Relish pathways,

SUBMITTER: Zuo H 

PROVIDER: S-EPMC11749392 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature