Synthesis and antimicrobial activity evaluation of pyrazole derivatives containing imidazothiadiazole moiety.

ABSTRACT:

Aim

The purpose of this work was to investigate the antimicrobial activity of pyrazole derivatives (21a - i and 23a - o) synthesized.

Materials & methods

The pyrazole derivatives were synthesized, molecular docked and tested for their antimicrobial activity, cytotoxicity, and hemolysis rate.

Results

Most of the target compounds showed high selective inhibitory activity against multi-drug resistance compared with other strains. Of these, compounds 21c (MIC = 0.25 µg/mL) and 23 h (MIC = 0.25 µg/mL) showed the strongest antibacterial activity, which was 4-flods than that of the positive control compound gatifloxacin (MIC = 1 µg/mL). Furthermore, compound 23 h showed no cytotoxicity to human LO2 cells, and did not show hemolysis even at ultra-high concentration.

Conclu

SUBMITTER: Han LY 

PROVIDER: S-EPMC11749441 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature