The sulfur-related metabolic status of <i>Aspergillus fumigatus</i> during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target.

ABSTRACT: Sulfur metabolism is an essential aspect of fungal physiology and pathogenicity. Fungal sulfur metabolism comprises anabolic and catabolic routes that are not well conserved in mammals, therefore is considered a promising source of prospective novel antifungal targets. To gain insight into Aspergillus fumigatus sulfur-related metabolism during infection, we used a NanoString custom nCounter-TagSet and compared the expression of 68 key metabolic genes in different murine models of invasive pulmonary aspergillosis, at 3 time-points, and under a variety of in vitro conditions. We identified a set of 15 genes that were consistently expressed at higher levels in vivo than in vitro, suggesting that they may be particularly relevant for intrapulmonary growth and thus c

SUBMITTER: Alharthi R 

PROVIDER: S-EPMC11749473 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature