Vitamin C derivative/AA2P promotes erythroid differentiation by upregulating <i>CA1</i>.

ABSTRACT: Vitamin C is used to treat anaemia; however, the mechanism through which vitamin C promotes erythroid differentiation is not comprehensively understood. The in vitro erythroid differentiation induction system can reveal the differentiation mechanism and provide erythrocytes for clinical transfusion and anaemia treatment. This process can be promoted by adding small-molecule compounds. In this study, we added l-ascorbic acid 2-phosphate sesquimagnesium salt hydrate (AA2P), a derivative of vitamin C, to an erythroid differentiation system induced from umbilical cord blood haematopoietic stem and progenitor cells in vitro and detected its effect on erythroid differentiation using single-cell transcription sequencing technology combined with non-targeted metabolism detection. AA2

SUBMITTER: Tan X 

PROVIDER: S-EPMC11749482 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature