Exploring fatigue in Marfan and hypermobile Ehlers-Danlos syndromes: an analytical cross-sectional study in two Italian healthcare centres.

ABSTRACT:

Objective

This study investigates the prevalence and underlying factors of fatigue in individuals with Marfan syndrome (MFS) and hypermobile Ehlers-Danlos syndromes (hEDS), highlighting the necessity for focused research on this symptom within these patient populations.

Design

Cross-sectional, multicentre study.

Setting

Data were collected from participants diagnosed with MFS or hEDS across multiple healthcare centres.

Participants

The study enrolled 282 participants (127 with MFS and 155 with hEDS).

Primary and secondary outcome measures

Fatigue was measured using the Fatigue Severity Scale (FSS). Additional assessments included the Patient Health Questionnaire-9 (PHQ-9) for depression and the Insomnia Severity Index (ISI) for sleep disturbances.

Res

SUBMITTER: Udugampolage N 

PROVIDER: S-EPMC11749496 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature