Lifetime progression of IgA nephropathy: a retrospective cohort study with extended long-term follow-up.

ABSTRACT:

Background

IgA nephropathy (IgAN) exhibits an unpredictable trajectory, creating difficulties in prognostication, monitoring, treatment, and research planning. This study provides a comprehensive depiction of the progression of kidney function throughout the disease course, from diagnosis to a span of 36 years post-diagnosis.

Methods

We utilized a cohort of 400 Norwegian IgAN patients, from diagnosis to the occurrence of death, initiation of kidney replacement therapy (KRT), or the latest follow-up. Recorded proteinuria (n = 2676) and creatinine (n = 8738) measurements were retrieved. Patients were divided into subgroups based on their specific estimated glomerular filtration rate (eGFR) slopes.

Results

Median follow-up was 16 years. During this period, 34% of patient

SUBMITTER: Rivedal M 

PROVIDER: S-EPMC11749578 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature