Rheumatoid arthritis and the risk of fracture: A Mendelian randomization study.

ABSTRACT: Observational epidemiological studies indicate a higher fracture incidence in rheumatoid arthritis (RA) patients compared to the general population. However, the causal relationship between RA and fracture risk, particularly traumatic and osteoporotic fractures, is not well established. We performed Mendelian randomization (MR) analysis to evaluate the causal relationship between RA and fracture risk. We performed a MR analysis using summary statistics from genome-wide association studies to investigate the causal association between RA and the risk of traumatic fractures at 9 sites and 3 types of osteoporotic fractures. The primary analysis used inverse-variance weighting, supplemented by MR-Egger regression and other methods to assess causal relationships and sensitivity analyses, includ

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11749589 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature