Management of uncomplicated acute appendicitis: a protocol for systematic review and network meta-analysis of randomised-controlled trials.

ABSTRACT:

Objectives

While multiple studies have shown the safety and efficacy of non-operative management, appendectomy remains the standard treatment for uncomplicated acute appendicitis (UAA). This study presents a protocol for a meta-analysis comparing antibiotic therapy, endoscopic retrograde appendicitis therapy (ERAT) and appendectomy in patients with UAA.

Methods and analysis

We will conduct a systematic search of several databases, including PubMed, Web of Science, Embase, the China National Knowledge Infrastructure and the Cochrane Library. The search will cover the full range of database records up to September 2024. Eligible studies will include randomised-controlled trials (RCTs) evaluating the efficacy of antibiotic therapy, ERAT and appendectomy for UAA. The primary out

SUBMITTER: Wang X 

PROVIDER: S-EPMC11749612 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature