Predictive value of myositis antibodies: role of semiquantitative classification and positivity for more than one autoantibody.

ABSTRACT:

Objectives

We assessed the positive predictive value (PPV) of 17 myositis antibodies for having a diagnosis of myositis and other myositis-spectrum conditions (interstitial lung disease (ILD), connective tissue diseases (CTD), malignancy) and evaluated the impact of semiquantitative classification and antibody overlap on the PPVs.

Materials and methods

We retrospectively identified 1068 individuals ≥18 years who tested positive for ≥1 antibody in the EUROLINE myositis line blot assay or positive for anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) in an ELISA-based test between 2015 and 2020 in 15 out of the 20 hospital districts in Finland. We extracted clinical diagnoses from the Care Register for Health Care between January 2013 and June 2022.

Results

The PPV

SUBMITTER: Kerola AM 

PROVIDER: S-EPMC11749618 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature