A vascularized bone-on-a-chip model development via exploring mechanical stimulation for evaluation of fracture healing therapeutics.

ABSTRACT: Bone is the major connective tissue maintaining the structural integrity of the human body. However, fracture and many skeletal degenerative diseases can compromise this function. Thus, therapeutics related to bone degeneration are of significant research interest and require good in vitro models for such therapeutic evaluation. Bone is a highly vascularized tissue and incorporation of this feature is significantly important for mimicking the osteogenic microenvironment. In the current study, we developed a vascularized flat bone model via simultaneous mechanical actuation of mechanical strain and fluid shear. The mechanical strain was achieved by static magnetic field actuation of a magnetic nanocomposite scaffold. The fluid shear was generated by developing a micropattern on the magnetic

SUBMITTER: Das B 

PROVIDER: S-EPMC11749731 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature